Intervention strategies of ischemia and reperfusion injury after ovarian tissue transplantation
10.3760/cma.j.cn101441-20200417-00219
- VernacularTitle:卵巢组织移植后缺血再灌注损伤的干预策略
- Author:
Meizi ZHANG
1
;
Li LIU
1
;
Fengqin XU
1
Author Information
1. 天津市第一中心医院生殖医学科 300192
- Publication Type:Journal Article
- Keywords:
Ovarian tissue transplantation;
Ischemia and reperfusion;
Angiogenesis;
Female fertility preservation
- From:
Chinese Journal of Reproduction and Contraception
2021;41(10):927-930
- CountryChina
- Language:Chinese
-
Abstract:
According to the statistics of new malignant tumors in China in 2015, there were 38 800 female patients under 30 years old, who urgently needed doctors' advices and suggestions on fertility protection and preservation. Ovarian tissue freezing method is the best way to preserve female endocrine function and fertility. At present, the key to the survival of ovarian tissue is to solve the problem of ischemia and reperfusion after ovarian transplantation. In this paper, we will systematically review the mechanism of ischemia and reperfusion after ovarian transplantation, as well as some intervention methods including antioxidants, angiogenesis and remote ischemic preconditioning. This will promote the combination of the latest biotechnology and medical technology, develop more effective, safer and operable solutions to improve the ischemic state after ovarian transplantation, and strive for early clinical use to address the increasing need for female fertility preservation.
