Renal calculus and acute renal failure secondary to hyperuricemia induced by mizoribine
10.3760/cma.j.cn114015-20220315-00204
- VernacularTitle:咪唑立宾致高尿酸血症继发肾结石和急性肾衰竭
- Author:
Wei WANG
1
;
Zhixiang JIA
1
;
Hua ZHOU
1
Author Information
1. 山西省第二人民医院肾移植透析中心一区，太原 030012
- Publication Type:Journal Article
- Keywords:
Hyperuricemia;
Kidney calculi;
Mizoribine;
Acute renal failure
- From:
Adverse Drug Reactions Journal
2023;25(1):57-59
- CountryChina
- Language:Chinese
-
Abstract:
A 37-year-old male patient was treated with tacrolimus, sirolimus, and methylprednisolone after renal transplantation to prevent rejection reaction. The function of the transplanted kidney recovered, serum creatinine was about 130 μmol/L, and serum uric acid was about 350 μmol/L. After 2 years and 6 months of renal transplantation, sirolimus was switched to mizolibin due to edema of his lower extremities. After taking mizolibin for 21 days, the patient developed nausea, poor appetite, and decreased urine volume (1 500 ml/24 h), and the symptoms gradually worsened. Laboratory tests showed serum creatinine 635 μmol/L and serum uric acid 1 750 μmol/L. The color Doppler ultrasonography of the transplanted kidney showed multiple stones and decreased color of blood flow signal. Acute renal failure, hyperuricemia, and calculus in transplanted kidney were diagnosed. Considering that it was related to mizolibin, the drug was discontinued and replaced by sirolimus, and hemodialysis, uric acid lowering, alkalizing urine, and other treatments were given. After 6 days of mizolibin discontinuation, the patient had no nausea or poor appetite. His urine volume was 3 000 ml/24 h, serum creatinine was 247 μmol/L and serum uric acid was 207 μmol/L. The color Doppler ultrasonography of the transplanted kidney showed no stone with abundant colorful blood flow signals. After 13 days of mizolibin discontinuation, the serum creatinine was 156 μmol/L and the serum uric acid was 123 μmol/L.
