Pharmaceutical Care in the Anti-infection Treatment of Nocardia brasiliensis-induced Brain Abscess:A Case Report
10.3870/j.issn.1004-0781.2025.07.024
- VernacularTitle:1例巴西诺卡菌致脑脓肿患者抗感染治疗的药学服务
- Author:
Jihua ZHAN
1
;
Zhenzhen DENG
;
Xia LUO
;
Ying YAN
Author Information
1. 湖南省衡阳市中心医院药学部,衡阳 421001
- Publication Type:Journal Article
- Keywords:
Nocardia brasiliensis;
Brain abscess;
Pharmacy practice
- From:
Herald of Medicine
2025;44(7):1165-1168
- CountryChina
- Language:Chinese
-
Abstract:
Objective To provide ideas and reference for the anti-infective drug treatment and pharmaceutical care of brain abscess caused by Nocardia brasiliensis.Methods Clinical pharmacists participated in the treatment of a patient with brain abscess caused by Nocardia brasiliensis.According to the patient's medical history,clinical symptoms,and test results,clinical pharmacists refer to the guidelines assisted physician to formulate the anti-infection treatment scheme of trimethoprim-sulfamethoxazole(SMZ-TMP)combined with imipenem/cilastatin and amikacin,and the pharmaceutical care.The dosage of amikacin was adjusted through therapeutic drug monitoring(TDM),and promptly identified adverse reactions such as myelosuppression caused by linezolid and SMZ-TMP.Results The physician adopted the pharmacist's suggestion,and the patient was discharged after treatment.Conclusion The anti-infection regimen for brain abscess caused by Nocardia brasiliensis depends on the drug sensitivity data of Nocardia,the severity of infection,the immune state of the host,and the PK/PD characteristics and adverse reactions of antibiotics.By participating in the pharmaceutical care of brain abscess caused by Nocardia brasiliensis,clinical pharmacists assisted physicians in optimizing drug treatment plans,ensuring the safety and effectiveness of clinical medication.
