Research advances in the correlation between follicular fluid proteomics and in vitro fertilization adverse pregnancy outcomes
10.3760/cma.j.cn101441-20190906-00408
- VernacularTitle:卵泡液蛋白质组学与体外受精不良妊娠结局相关性研究进展
- Author:
Li LI
1
;
Zhengao SUN
;
Dandan GAO
;
Yingjie MA
;
Xinlei WANG
;
Yi ZHANG
Author Information
1. 山东中医药大学第一临床医学院，济南 250014
- Publication Type:Journal Article
- Keywords:
Fertilization in vitro;
Follicular fluid;
Proteomics;
Adverse pregnancy outcomes
- From:
Chinese Journal of Reproduction and Contraception
2020;40(10):809-813
- CountryChina
- Language:Chinese
-
Abstract:
In vitro fertilization (IVF) is a routine treatment for infertility diseases, but there are low pregnancy success rates and corresponding adverse pregnancy outcomes. In the post-gene era, human follicular fluid studies based on proteomics can provide substantial information about the various steps of the IVF process and contribute to predict or improve IVF pregnancy outcomes. By searching the PubMed, Scopus, and Web of Science databases, this paper reviews recent advances in studies related to IVF pregnancy outcomes based on human follicular fluid proteomics. The aim is to summarize the potential markers that can be used to optimize IVF outcomes while providing insights into IVF failure mechanisms, which can facilitate basic research in reproductive medicine, thereby accelerating clinical transformation.
