Differential Diagnosis of Prostate Cancer from Benign Prostatic Hyperplasia Using 5.0T Multiparametric MRI with Histogram Analysis
10.3969/j.issn.1005-5185.2025.07.007
- VernacularTitle:5.0T多参数MRI结合直方图定量分析对前列腺癌和良性前列腺增生的鉴别诊断
- Author:
Chengfeng ZHENG
1
;
Sen XING
;
Xinghua LIU
;
Wenbing ZENG
;
Shaoxin XIANG
;
Huan MA
Author Information
1. 四川省内江市第一人民医院放射科,四川 内江 641000;锦州医科大学研究生学院,辽宁 锦州 121001
- Publication Type:Journal Article
- Keywords:
Prostatic neoplasms;
Prostatic hyperplasia;
Magnetic resonance imaging;
Diffusion-weighted imaging;
Ultra-high field;
ROC curve;
Area under curve;
Diagnosis,differential
- From:
Chinese Journal of Medical Imaging
2025;33(7):723-729
- CountryChina
- Language:Chinese
-
Abstract:
Purpose To evaluate the efficacy of ultra-high field 5.0T MRI combined with histogram analysis for diagnosing prostate cancer and benign prostatic hyperplasia.Materials and Methods This retrospective analysis included data from 63 patients with prostatic diseases at the Chongqing University Three Gorges Hospital from January to May 2024,comprising 31 cases of prostate cancer and 32 cases of benign prostatic hyperplasia.MRI sequences included T2WI,T1WI,diffusion-weighted imaging,intravoxel incoherent motion and T2 mapping.Histogram data of apparent diffusion coefficient,true diffusion coefficient,pseudo-diffusion coefficient,perfusion fraction and T2 relaxation time were calculated,and diagnostic efficacy was assessed using the area under the receiver operating characteristic curve.Results In prostate cancer,the 10th percentile,the 90th percentile,mean,median,and minimum values of histogram parameters from apparent diffusion coefficient,true diffusion coefficient,pseudo-diffusion coefficient,perfusion fraction and T2 mapping were significantly lower than those of benign prostatic hyperplasia(Z=-6.036--3.368,all P<0.05).Notably,the combined model of apparent diffusion coefficient,intravoxel incoherent motion and T2 mapping parameters achieved an the area under the curve of 0.987,with sensitivity and specificity of 96.77%and 96.87%,respectively.Conclusion This study confirms that 5.0T MRI histogram analysis technique demonstrates significant diagnostic efficacy in differentiating prostate cancer from benign prostatic hyperplasia.
