Research progress in pathogenesis of drug-induced liver injury caused by reactive metabolites
10.3760/cma.j.cn114015-20220517-00439
- VernacularTitle:反应性代谢产物致药物性肝损伤的机制研究进展
- Author:
Yicong BIAN
1
;
Liyan MIAO
;
Limei ZHAO
Author Information
1. 中国医科大学附属盛京医院药学部，沈阳 110004
- Publication Type:Journal Article
- Keywords:
Chemical and drug induced liver injury;
Metabolic side effects of drugs and substances;
Cytochrome P-450 enzyme system;
Oxidative stress;
Immune reaction
- From:
Adverse Drug Reactions Journal
2022;24(11):599-603
- CountryChina
- Language:Chinese
-
Abstract:
Reactive metabolites is one of the main causes of drug-induced liver injury (DILI). After entering the body, some drugs can be metabolized by liver to generate drug reactive metabolites, which can deplete glutathione, and in turn bind to macromolecules such as proteins or nucleic acids in the body, alter biomacromolecule function, induce cellular oxidative stress and the body′s immune response, interfere with the body′s normal physiological function, and produce hepatotoxicity. Reactive metabolites mediated DILI may be not the action of one mechanism, but the combined effects of multiple mechanisms. This article reviews the production process of drug reactive metabolites, the mechanism of liver injury, and the means of prevention and treatment, providing an important reference for clinical safe drug use.
