Hypokalemia and hypocalcemia induced by caspofungin for injection
10.3760/cma.j.cn114015-20220406-00286
- VernacularTitle:注射用卡泊芬净致低钾和低钙血症
- Author:
Baoping XU
1
;
Hao YANG
1
;
Qiguo WEI
1
;
Huaiwen PENG
1
Author Information
1. 安徽中医药大学附属六安市中医院重症医学科，六安 237000
- Publication Type:Journal Article
- Keywords:
Hypokalemia;
Hypocalcemia;
Caspofungin
- From:
Adverse Drug Reactions Journal
2023;25(1):55-57
- CountryChina
- Language:Chinese
-
Abstract:
A 35-year-old female patient with diabetes ketoacidosis received insulin, meropenem, ganciclovir, correction of acidosis, and fluid infusion due to pulmonary infection. Because sputum culture results suggested aspergillus infection, ganciclovir was stopped and replaced by caspofungin; because the patient′s peak temperature dropped, meropenem was stopped and replaced by piperacillin sodium and tazobactam sodium. Before antibacterial treatments, the blood potassium and calcium were 3.7 mmol/L and 2.07 mmol/L, respectively, and the blood potassium and calcium were 3.5 and 2.18 mmol/L, 3.0 and 1.89 mmol/L, 2.6 and 1.96 mmol/L, and 3.0 and 1.97 mmol/L, respectively on the 3rd, 6th, 8th, and 10th days after using caspofungin and on the 2nd, 3rd, 7th, and 9th days of treatment with piperacillin sodium tazobactam sodium. Piperacillin sodium tazobactam sodium was stopped, caspofungin, potassium and calcium supplements, and other symptomatic treatments were continued. Two days later, blood potassium was 3.0 mmol/L and blood calcium was 1.96 mmol/L. Then caspofungin was stopped and replaced by voriconazole. Three days later, the blood potassium was 3.8 mmol/L and the blood calcium was 2.12 mmol/L. It was considered that the hypokalemia and hypocalcemia were possibly induced by caspofungin.
