Research progress of immune checkpoint inhibitor-induced acute kidney injury

VernacularTitle:免疫检查点抑制剂相关急性肾损伤研究进展
Author: Yunyan BI ¹ ; Ping GAO ; Nan GUO ; Shan YUAN ; Wen ZHANG
Author Information

1. 山东第一医科大学（山东省医学科学院）研究生部，济南　250117
Publication Type:Journal Article
Keywords: Immune checkpoint inhibitors; Acute kidney injury; Immune-related adverse effects
From: Adverse Drug Reactions Journal 2023;25(1):47-52
CountryChina
Language:Chinese
Abstract: With the application of immune checkpoint inhibitors (ICIs), the acute kidney injury (AKI) caused by ICIs has attracted increasingly extensive attention. The incidence of ICIs-induced AKI is 0.8%-29%, which can occur weeks or months after the first drug use or even after drug withdrawal. The typical renal histopathological features of AKI are acute tubulointerstitial nephritis, and glomerulopathy can also be seen. The risk factors include combined application of ICIs, the use of proton pump inhibitors, and having chronic kidney diseases, etc. After the diagnosis of AKI, it is necessary to decide whether to reduce the dose or stop using ICIs and start glucocorticoid treatment or add other immunosuppressive drugs according to the degree of disease and the specific situation of the patient. In case of level 3-4 AKI, ICIs shall be permanently discontinued.