Pathogenic mechanism and reproductive outcomes in globozoospermia: an update
10.3760/cma.j.cn101441-20190816-00359
- VernacularTitle:圆头精子症致病机制及临床妊娠结局相关研究进展
- Author:
Yelin JIA
1
;
Fuping LI
Author Information
1. 四川大学华西第二医院人类精子库，成都 610061
- Publication Type:Journal Article
- Keywords:
Globozoospermia;
Teratozoospermia;
Genetic mutation;
Reproductive techniques, assisted;
Male infertility
- From:
Chinese Journal of Reproduction and Contraception
2020;40(10):859-863
- CountryChina
- Language:Chinese
-
Abstract:
Globozoospermia is a rare (0.1%) but severe disorder in male infertility, with round-headed and acrosomeless sperm defects. The pathogenesis of globozoospermia most probably originates in spermiogenesis, more specifically in acrosome formation and sperm head elongation. It is confirmed with genetic origin. Five human genes and 17 mouse genes have been so far confirmed in presenting globozoospermia. Intracytoplasmic sperm injection (ICSI) combined with assisted oocyte activation (AOA) has been proved to be a very efficient fertilization technique when compared with conventional ICSI in globozoospermia. In this paper, the discovery, recognition and definition of round head sperm, morphological characteristics and ultrastructure, related genes and pathogenesis, and the outcome of assisted reproduction in globozoospermic patients were summarized and discussed.
