Liver injury induced by parenteral nutrition
10.3760/cma.j.cn114015-20220211-00113
- VernacularTitle:肠外营养致肝损伤
- Author:
Xiuli CHENG
1
;
Qingjun JIANG
;
Jin HU
Author Information
1. 宁夏回族自治区人民医院药学部，银川 750000
- Publication Type:Journal Article
- Keywords:
Parenteral nutrition;
Fat emulsions, intravenous;
Chemical and drug induced liver injury
- From:
Adverse Drug Reactions Journal
2022;24(10):551-553
- CountryChina
- Language:Chinese
-
Abstract:
A 54-year-old female patient with aortic dissection received parenteral nutrition treatments due to malnutrition risk, including IV infusions of fat emulsion amino acid (17) and glucose (11%) injection 1 440 ml once daily, compound amino acid injection (18 AA-II) 250 ml once daily, and medium and long chain fat emulsion injection (C6-24) 250 ml once daily. Other treatments included drugs to maintain blood pressure and control heart rate, analgesics, 10% potassium chloride injection, etc. The laboratory tests before treatments showed alanine aminotransferase (ALT) 36 U/L, aspartate aminotransferase (AST) 35 U/L, γ-glutamyl transpeptidase (γ-GT) 51 U/L, total bilirubin (TBil) 8.3 μmol/L, and alkaline phosphatase (ALP) 129 U/L. After 8 days of parenteral nutrition treatments, laboratory tests showed ALT 343 U/L, AST 357 U/L, γ-GT 343 U/L, TBil 21.4 μmol/L, and ALP 376 U/L. The liver injury caused by parenteral nutrition was considered. Parenteral nutrition was stopped, other treatments were continued, and liver-protective treatments such as glutathione combined with diethylamine dichloroacetate were given. Eight days later, the laboratory test showed ALT 42 U/L, AST 29 U/L, γ-GT 55 U/L, TBil 8.4 μmol/L, and ALP 107 U/L.
