Hyponatremia due to paroxetine
10.3760/cma.j.cn114015-20220610-00505
- VernacularTitle:帕罗西汀致低钠血症
- Author:
Xing JIN
1
;
Hua ZHOU
;
Zhangfeng YU
Author Information
1. 苏州市立医院药学部，苏州 215001
- Publication Type:Journal Article
- Keywords:
Epilepsy;
Paroxetine;
Hyponatremia;
Antidepressive agents
- From:
Adverse Drug Reactions Journal
2023;25(3):178-180
- CountryChina
- Language:Chinese
-
Abstract:
A 44-year-old male patient received sodium valproate tablets 0.2 g and carbamazepine 0.1 g twice daily orally for a long time due to epilepsy, rabeprazole sodium enteric-coated tablets 10 mg once daily orally for a long time due to duodenal ulcer. Due to poor efficacy, the antiepileptic drug was adjusted to sodium valproate sustained-release tablets 0.5 g orally twice daily in combination with levetiracetam 0.25 g orally twice daily, and paroxetine 20 mg orally once daily because of depression was given at the same time. After about 3 months of treatments, the patient repeatedly suffered from limb convulsions, and the laboratory test showed serum sodium 128 mmol/L. Oral and intravenous sodium supplementation were given for 16 days, but his blood sodium level was still less than 130 mmol/L. It was considered that the hyponatremia of the patient might be caused by drugs. After stopping paroxetine, the patient′s blood sodium concentration returned to 140 mmol/L 2 days later.
