Advances in the genetics of obstructive azoospermia

VernacularTitle:梗阻性无精子症的遗传学研究进展
Author: Chencheng YAO ¹ ; Peng LI ; Ruhui TIAN ; Liangyu ZHAO ; Chao YANG ; Huixing CHEN ; Erlei ZHI ; Yuhua HUANG ; Li ZHANG ; Yunpeng PENG ; Zheng LI
Author Information

1. 上海交通大学附属第一人民医院泌尿外科中心男科,　男性健康评估中心,　上海市生殖医学重点实验室　200080
Publication Type:Journal Article
Keywords: Male infertility; Obstructive azoospermia; Genetics
From: Chinese Journal of Reproduction and Contraception 2020;40(12):1038-1042
CountryChina
Language:Chinese
Abstract: Azoospermia accounts for 10%-15% of male infertility, with the prevalence of 1% in male population. Obstructive azoospermia (OA) accounts for 40% of azoospermia and can be caused by a variety of factors, including male reproductive duct inflammation and genetic factors. Given the fact that the spermatogenesis is normal in the testis of OA patients, the OA patients can have their own offspring through testicular biopsy and sperm retrieval followed by assisted reproductive technology (ART). Therefore, the genetic etiology of OA is often overlooked. Subsequently, studies of the following ART strategies and offspring birth defects are also ignored. This article reviewed the genetic disorders of OA patients, and the animal model with OA, providing new ideas for management of OA patients, genetic counseling, and development of male contraceptives.