Identifying the best predictor of late-onset severe ovarian hyperstimulation syndrome in ≤35 years old women undergoing ovarian stimulation
10.3760/cma.j.cn101441-20191102-00495
- VernacularTitle:年龄≤35岁行卵巢刺激患者迟发重度卵巢过度刺激综合征的最佳预测因子探析
- Author:
Huihui WANG
1
;
Xiazhu CHEN
1
;
Yuan SUN
1
;
Lei WANG
1
Author Information
1. 广州医科大学附属第三医院生殖医学中心 510150
- Publication Type:Journal Article
- Keywords:
Ovarian hyperstimulation syndrome;
Gonadotropin;
Number of oocytes retrieved;
Gestational sacs;
Pregnancy
- From:
Chinese Journal of Reproduction and Contraception
2020;40(11):899-905
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To identify the best predictor of late-onset severe ovarian hyperstimulation syndrome (OHSS) in ≤35 years old women undergoing ovarian stimulation.Methods:In this retrospective cohort study, the data from 1138 in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) cycles at the Third Affiliated Hospital of Guangzhou Medical University from December 2017 to December 2018 were analyzed. The pregnancy cycles were compared between OHSS group and non-OHSS group. The differences were calculated for two groups using one-way ANOVA and chi-squared test. Factors were identified to predict late onset OHSS using multivariable logistic regression. Receiver operating characteristic (ROC) curves were used to evaluate the predictors of OHSS. Results:Antral follicle count (AFC) ( P=0.009), estradiol levels on human chorionic gonadotropin (hCG) injection day ( P<0.001), the number of oocytes retrieved ( P=0.001), available embryos ( P=0.016) and high-quality embryos ( P=0.007) were higher, whereas, priming dosage of exogenous follicle-stimulating hormone (FSH) ( P=0.002), total dosage of gonadotropin (Gn) used ( P<0.001) and stimulation duration ( P=0.034) were lower in OHSS group than in non-OHSS group. The number of gestational sacs was higher in OHSS group than in non-OHSS group ( P<0.001). The number of gestational sacs ( OR=2.408, 95% CI=1.529-3.793, P<0.001) was found to be independent predictive factors of late onset OHSS in ≤35 years old women. Linear predictor (lp)=number of gestational sacs ×0.879-3.946. The risk ratio of OHSS was 2.25 for patients with the number of gestational sacs ≥2 compared with those with 1 gestational sacs. Conclusion:In ≤35 years old women, the number of gestational sacs was the independent predictive factor of late-onset severe OHSS, which was higher when ≥2 gestational sacs occurred.
