Effects of gonadotropin-releasing hormone antagonist on endometrial receptivity
10.3760/cma.j.cn101441-20191013-00457
- VernacularTitle:促性腺激素释放激素拮抗剂对子宫内膜容受性的影响
- Author:
Yifei SUN
1
;
Yueming XU
1
;
Guimin HAO
1
Author Information
1. 河北医科大学第二医院生殖医学科， 石家庄050000
- Publication Type:Journal Article
- Keywords:
Gonadotropin-releasing hormone antagonist;
Endometrial receptivity;
Pregnancy outcome
- From:
Chinese Journal of Reproduction and Contraception
2020;40(10):794-797
- CountryChina
- Language:Chinese
-
Abstract:
The gonadotropin-releasing hormone antagonist (GnRH-A) protocol has been widely used in the field of assisted reproductive technology. Compared with the classical GnRH-agonist (GnRH-a) protocol, it has many advantages: 1) a rapid reduction of gonadotropin use after inhibiting the early onset of luteinizing hormone (LH) peak effect; 2) the rapid cessation of the drug; 3) the reduction of the occurrence of ovarian hyperstimulation syndrome (OHSS). However, early randomized and controlled trials showed that the pregnancy rate of antagonist protocol-users were lower than that of traditional agonist protocol-users. Other medical research reports concluded that although the implantation rate of a fresh cycle of antagonist protocol decreased, the implantation rate and the clinical pregnancy rate of a subsequent frozen-thawed embryo transfer were not affected. It was concluded that the GnRH-A might change the receptivity of endometrium, but it didn't have an effect on the quality of oocyte and embryo development. This conclusion is debatable. Therefore, this paper reviews the effects of GnRH-A on endometrial receptivity from the aspects of endometrial ultrasound imaging, morphological levels, protein levels, gene levels and pregnancy outcomes.
