Research progress of the relationship between non-coding RNA and gestational diabetes mellitus

VernacularTitle:非编码RNA与妊娠期糖尿病关系的研究进展
Author: Weiqiang ZHU ¹ ; Zhaofeng ZHANG ; Min LI ; Jianhua XU ; Shangqing LIU ; Weijin ZHOU ; Jing DU
Author Information

1. 复旦大学生殖与发育研究院上海市计划生育科学研究所，国家卫生健康委员会计划生育药具重点实验室　200032
Publication Type:Journal Article
Keywords: Gestational diabetes mellitus; Long non-coding RNA; MicroRNA; Circular RNA
From: Chinese Journal of Reproduction and Contraception 2020;40(10):853-858
CountryChina
Language:Chinese
Abstract: With the increase of obesity and type 2 diabetes, gestational diabetes mellitus (GDM) is growing public health problem worldwide. GDM is one of the most ubiquitous diseases affecting pregnancy outcomes in perinatal women, which increases the incidence of adverse outcomes such as miscarriage, macrosomia, premature birth and stillbirth. Non-coding RNA (ncRNA) plays an important role in regulating the occurrence and development of GDM, and it is also related to the occurrence of complications of GDM. NcRNA is a type of RNA that don't encode proteins, including long non-coding RNA (LncRNA), microRNA (miRNA) and circular RNA (circRNA). More and more studies show ncRNA contains abundant information. This review discusses the relationship between three kinds of ncRNA and GDM, in aim to provide theoretical basis for further research on gestational diabetes.