Acute severe liver injury induced by Xingqi Sanjie cream (行气散结膏)
10.3760/cma.j.cn114015-20220324-00245
- VernacularTitle:行气散结膏致急性重度肝损伤
- Author:
Jinchun LIU
1
;
Xiaomin YAN
Author Information
1. 南京鼓楼医院药学部，南京临床药学中心，南京 210008
- Publication Type:Journal Article
- Keywords:
Drugs, Chinese herbal;
Drug induced liver injury;
Xingqi Sanjie cream
- From:
Adverse Drug Reactions Journal
2022;24(12):667-669
- CountryChina
- Language:Chinese
-
Abstract:
A 38-year-old female patient with thyroid nodule received Xingqi Sanjie cream 30 g orally twice daily for 4 treatment courses in total. Each treatment course was 1 month and the interval between the 2 courses was 14 days. On the 29th day of the 4th treatment course, the patient developed poor appetite, yellowish skin and sclera, and dark urine. Laboratory tests showed alanine aminotransferase (ALT) 3 201 U/L, aspartate aminotransferase (AST) 2 262 U/L, total bilirubin (TBil) 257.2 μmol/L, direct bilirubin (DBil) 186.9 μmol/L, and alkaline phosphatase (ALP) 159 U/L. Drug-induced liver injury (severe) was diagnosed, which was considered to be related to Xingqi Sanjie cream. The drug was stopped, and symptomatic and supportive treatments including hepatoprotection and rehydration were given. Twenty-two days later, the above symptoms in the patient were improved. Laboratory tests showed ALT 209 U/L, AST 117 U/L, TBil 92.7 μmol/L, DBil 63.2 μmol/L, and ALP 82 U/L. Fifty-one days later, the yellowish skin and sclera in the patient subsided, and the urine color returned to normal. Laboratory tests showed ALT 37 U/L, AST 22 U/L, TBil 30.3 μmol/L, DBil 14.7 μ mol/L, and ALP 58 U/L.
