5.0T MRI Susceptibility-Weighted Imaging in Differential Diagnosis Between Hepatocellular Carcinoma and Mass-Forming Intrahepatic Cholangiocarcinoma
10.3969/j.issn.1005-5185.2025.07.005
- VernacularTitle:5.0T MRI磁敏感加权成像在肝细胞癌与肿块型肝内胆管癌鉴别诊断中的应用
- Author:
Xudan CHEN
1
;
Shaopeng LI
;
Dawei YIN
;
Liangliang HUANG
;
Lijun DONG
;
Xiaopeng SONG
;
Ying LIU
Author Information
1. 中国科学技术大学附属第一医院(安徽省立医院)影像科,安徽 合肥 230001
- Publication Type:Journal Article
- Keywords:
Carcinoma,hepatocellular;
Cholangiocarcinoma;
Magnetic resonance imaging;
Susceptibility-weighted imaging;
Ultra-high field;
Pathology,surgical;
Diagnosis,differential
- From:
Chinese Journal of Medical Imaging
2025;33(7):712-716,729
- CountryChina
- Language:Chinese
-
Abstract:
Purpose To evaluate the differential diagnostic value of 5.0T MRI susceptibility-weighted imaging(SWI)in hepatocellular carcinoma(HCC)and mass-forming intrahepatic cholangiocarcinoma(MICC).Materials and Methods A total of 56 patients with HCC and 36 patients with MICC confirmed by pathology from March 2023 to November 2024 in Anhui Provincial Hospital were retrospectively enrolled.Two radiologists independently analyzed three features of the lesions,including the low-signal rims around the lesion,hemorrhage within the lesion,and the relationship between lesions and adjacent vessels,on the SWI sequence between the two groups,respectively,via inter-rater consistency analysis.These above features between the two groups were compared and contrasted them with those obtained from conventional MR plain and enhanced scans,respectively.For intralesional hemorrhages,the diagnostic value was quantified by calculating the internal tissue susceptibility signal.Results The radiologists showed good consistency in the low-signal rims,intratumoral hemorrhage as well as the relationship between the lesion and the blood vessel on the SWI in the HCC group and the MICC group(Kappa=0.802-0.929,all P<0.001).Compared with conventional MR plain,SWI significantly enhanced the detection rates of perilesional low-signal rims and intratumoral hemorrhage(χ2=89.409,46.210,both P<0.001).These findings were more prevalent in HCC patients.The internal tissue susceptibility signal grading showed that HCC predominantly exhibited grade 3,whereas MICC predominantly exhibited grade 1,with statistically significant differences(Z=-4.059,P<0.05).Additionally,compared with enhanced MRI,SWI demonstrated higher accuracy in diagnosing the relationship between lesions and blood vessels in both groups;however,these differences were not statistically significant(χ2=0.275,0.247,P=0.871,0.619).In the HCC group,the relationship between tumors and blood vessels was primarily characterized by compression and tumor thrombus formation,while in the MICC group,it was predominantly marked by invasive changes,including vessel encasement,stenosis or occlusion,with a statistically significant difference between the two groups(Z=-6.809,P<0.001).Conclusion SWI sequence of 5.0T MRI provides clear visualization of the internal and peripheral structures of HCC and MICC.It can accurately delineate the relationship between lesions and blood vessels without the need for contrast agents,offering significant clinical utility in differentiating these two conditions.
