Characteristics of patients who can benefit from endometrial microstimulation and how to maximize the efficacy: a retrospective case-control study of Chinese women
10.3760/cma.j.cn101441-20190912-00417
- VernacularTitle:子宫内膜微刺激受益的人群特征以及如何最大化这种效益:一项针对中国女性的回顾性病例对照研究
- Author:
Tingting ZHOU
1
;
Jing LI
;
Na YU
;
Tianxiang NI
;
Caiyi HUANG
;
Qian ZHANG
;
Junhao YAN
Author Information
1. 山东大学生殖医学研究中心，济南 250012
- Publication Type:Journal Article
- Keywords:
Reproductive technology, assisted;
Embryo implantation;
Luteal phase;
Endometrium
- From:
Chinese Journal of Reproduction and Contraception
2020;40(6):461-468
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To find out a specific group of patients undergoing in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) who can benefit from endometrial microstimulation (EM) and how to maximize the effect. Methods:A retrospective case-control study on 1916 cycles from women who underwent EM in Center for Reproductive Medicine, Shandong University between 2006 to 2018. Their baseline characteristics and cycle parameters were analyzed as well as the differences in EM procedures. Results:There were 1435 cycles from women ≤35 years old (867 succeeded in implantation and 568 failed) and 481 cycles from women >35 years old (179 succeeded in implantation and 302 failed). Among women ≤35 years old, compared with those who failed to implant, those who succeeded had thicker endometrium [(1.07±0.20) cm vs. (1.02±0.20) cm, OR=5.01, P<0.001] and a larger proportion of A/A- endometrial type (91.3% vs. 85.3%, OR=1.88, P=0.01) observed on trigger day. As for patients >35 years old, women who succeeded in implantation had thicker endometrium than those who failed in implantation [(1.05±0.19) cm vs. (0.96±0.22) cm, OR=8.73, P<0.001]. In addition, EM in luteal phase resulted in a significantly higher implantation rate in the >35 years old group compared with that when EM in follicular phase (42.9% vs. 32.7%, P=0.02). Conclusion:As for patients who were suggested to do the EM therapy, those ≤ 35 years old with better endometrium condition (thicker and A/A- endometrial type) or women >35 years old with thicker endometrium may benefit from EM, and EM in luteal phase increases implantation rates among >35-year-old patients compared with that when EM in follicular phase.
