Effects of phloroglucinol on transfer outcome of in vitro fertilization-embryo transfer
10.3760/cma.j.cn101441-20190626-00277
- VernacularTitle:间苯三酚对体外受精-胚胎移植结局的影响
- Author:
Xujing GENG
1
;
Genhong MAO
1
;
Dongmei ZHAO
1
;
Yungai XIANG
1
;
Dan ZHANG
1
;
Yuxia SONG
1
;
Meng WANG
1
;
Guo YU
1
;
Li TAN
1
Author Information
1. 郑州大学第二附属医院生殖医学部 450000
- Publication Type:Journal Article
- Keywords:
Fertilization in vitro;
Embryo transfer;
Phloroglucinol;
Pregnancy outcome
- From:
Chinese Journal of Reproduction and Contraception
2020;40(7):547-553
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the effects of phloroglucinol on transfer outcome of in vitro fertilization-embryo transfer (IVF-ET). Methods:Retrospective analysis of 4289 cases of infertility patients treated with IVF-ET in the Department of Reproductive Medicine, the Second Affiliated Hospital of Zhengzhou University from January 1, 2015 to November 30, 2018 was performed. According to the pregnancy outcome, all patients were divided into pregnancy group and non-pregnancy group to analyze the risk factors affecting the pregnancy outcome. According to medication before transfer, all patients were divided into no medication group (group A), preoperative intravenous infusion of atosiban group (group B), preoperative and intraoperative injection of atosiban group (group C) and interoperative intravenous infusion of phloroglucinol group (group D). The pregnancy outcomes, occurrence of adverse reactions during and after treatment were compared among the four groups.Results:Age, number of high-quality embryos, and medication methods before transfer were independent factors influencing pregnancy outcomes in patients undergoing IVF-ET ( P=0.031, P=0.039, P=0.020). The embryo implantation rate, the biochemical pregnancy rate and the clinical pregnancy rate of group D were significantly higher than those in group A (all P<0.001), group B (all P<0.001) and group C ( P<0.001， P<0.001， P=0.001), while the ectopic pregnancy rate was significantly lower than that in group A, group B and group C (all P<0.001). The abortion rate in group D was lower than that in group A ( P<0.001). During treatment period and after treatment, there were no discomfort complains and allergic reactions in the four groups. There were no birth defects in all born babies. Conclusion:The medication method is an independent factor influencing pregnancy outcomes of patients undergoing IVF-ET. Intraoperative intravenous infusion of phloroglucinol can significantly increase embryo implantation rate and pregnancy rate of IVF-ET patients, and reduce their abortion rate.
