Research progress on biological characteristics and immune regulation of metallothionein
10.3969/j.issn.1000-484X.2025.09.036
- VernacularTitle:金属硫蛋白的生物学特性及其免疫调节作用研究进展
- Author:
Siyin HE
1
;
Ruiting WEN
1
;
Zhigang YANG
1
Author Information
1. 广东医科大学附属湛江中心医院血液内科,湛江 524045
- Publication Type:Journal Article
- Keywords:
Metallothionein;
Biological functions;
Immune regulation;
Immune cell
- From:
Chinese Journal of Immunology
2025;41(9):2272-2277
- CountryChina
- Language:Chinese
-
Abstract:
Metallothionein(MT)is a group of low molecular weight metal-binding proteins rich in cysteine,which plays an important role in heavy metal detoxification,antioxidant,immune defense,cell proliferation,differentiation,and angiogenesis.In re-cent years,studies have found that MT can interact with a variety of immune cells to regulate innate and adaptive immune responses,thus playing an important role in the development of tumors,inflammatory diseases and autoimmune diseases.Therefore,this article reviews the biological characteristics of MT and its immunomodulatory effects,in order to provide new ideas for targeted therapy targeting MT.
