Esophagitis due to alendronate sodium
10.3760/cma.j.cn114015-20220610-00513
- VernacularTitle:阿仑膦酸钠致食管炎
- Author:
Yanhao CHEN
1
;
Xiaobin ZHOU
1
;
Shuang FAN
1
;
Xiaodong WANG
1
;
Liwei DUAN
1
Author Information
1. 吉林大学第二医院胃肠内科及消化内镜中心，长春 130041
- Publication Type:Journal Article
- Keywords:
Ulcer;
Drug-related side effects and adverse reaction;
Alendronate
- From:
Adverse Drug Reactions Journal
2022;24(9):490-491
- CountryChina
- Language:Chinese
-
Abstract:
A 62-year-old female osteoporosis patient received alendronate sodium 70 mg orally once a week (taking the drug 30 minutes before breakfast with plenty of water and keeping upright during and after taking drug for a while). After taking the drug for 3 times, the patient developed retrosternal pain on swallowing with occasional acid aversion and epigastric dull pain. Gastroscopy showed multiple shallow ulcers, with yellow and white fur on the surface, in the esophagus 20 cm to 37 cm from the incisors. Esophagitis was considered, which might be related to alendronate sodium. Alendronate was stopped, and the treatments of acid suppression, mucosal repair, proper rehydration, and total liquid intake were given. Two days later, the stabbing pain behind the sternum was relieved; 7 days later, the pain was obviously relieved and symptoms of the acid aversion and epigastric dull pain disappeared; 1 month later, the retrosternal pain on swallowing disappeared.
