Association of 41 circulating interleukins and growth factors with risk of seronegative rheumatoid arthritis:A Mendelian randomization study
10.3969/j.issn.1000-484X.2025.09.006
- VernacularTitle:41种细胞因子和生长因子与血清阴性的类风湿关节炎的因果关系:一项双样本孟德尔随机化研究
- Author:
Yi LING
1
;
Nina REN
1
;
Qiuyi WANG
1
;
Xueming YAO
1
;
Wukai MA
1
Author Information
1. 贵州中医药大学第二临床医学院,贵阳 550000
- Publication Type:Journal Article
- Keywords:
Serum cytokines;
Seronegative rheumatoid arthritis;
Mendelian randomization;
Causality
- From:
Chinese Journal of Immunology
2025;41(9):2081-2086
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the association of serum levels of 41 serum cytokines and growth factors with the risk of sero-negative rheumatoid arthritis(SNRA)by Mendelian randomization.Methods:Genetic instruments for 41 circulating cytokines and growth factors were determined from a genome-wide association study(GWAS)of 8 293 European participants.Summary statistics for the SNRA were obtained from the Finnish database,including 3 877 SNRA cases and 285 035 controls of European ancestry.All of the inverse variance weighted(IVW),weighted median method(WM)and MR-Egger regression were used for MR analysis,while the IVW method was considered as the main analysis.The sensitivity analysis included a heterogeneity test,horizontal pleiotropic test,and leave-one method test to determine the reliability of the MR results.Results:In the IVW method,TNF-α[OR=1.470,95%CI(1.1331～1.910),P=0.004],IP-10[OR=0.794,95%CI(0.660～0.955),P=0.015]and IL-2rα[OR=0.049,95%CI(0.856～0.999),P=0.049].Sensitivity analysis showed no heterogeneity and horizontal pleiotropy.Conclusion:TNF-α,IP-10 and IL-2rα are causally associated to SNRA.TNF-α increases the risk of SNRA,while IP-10 and IL-2rα reduce the risk of SNRA.
