Kaposi′s sarcoma induced by cyclophosphamide combined with ciclosporin

VernacularTitle:环磷酰胺与环孢素联用致卡波西肉瘤
Author: Fengyi TANG ¹ ; Wei KONG ; Qing SHU ; Weihong GE ; Yuzhu PENG ; Hong WANG
Author Information

1. 中国药科大学南京鼓楼医院药学部，南京　210008
Publication Type:Journal Article
Keywords: Sarcoma, Kaposi; Immunosuppressive agents; Cyclophosphamide; Cyclosporine
From: Adverse Drug Reactions Journal 2022;24(8):441-443
CountryChina
Language:Chinese
Abstract: A 62-year-old female patient with systemic vasculitis was treated with glucocorticoid and cyclophosphamide for a long time, and then cyclosporine was added due to poor control of the disease. After more than 4 months of cyclosporine treatment, the patient developed a dark red rash on the right lower limb. Later, skin biopsy was performed and pathological examination and immunohistochemical test results suggested Kaposi′s sarcoma. No abnormality was found in the blood lymphocyte subsets count of the patient, and the immune deficiency diseases were not considered. Kaposi′s sarcoma was considered to be related to the immunosuppressive drugs. Cyclophosphamide and cyclosporine were switched to Leigongteng Duogan (雷公藤多苷) and the dose of glucocorticoid was reduced. Seven days later, the rash in the patient was improved; more than 2 months later, the rash on the patient′s right lower limb subsided and the skin was smooth without swelling.