Research progress of glucose metabolism in oocyte maturation
10.3760/cma.j.cn101441-20190731-00336
- VernacularTitle:葡萄糖代谢与卵母细胞成熟
- Author:
Yuexin ZHANG
1
;
Lingjun LI
1
;
Yugui CUI
1
Author Information
1. 南京医科大学第一附属医院生殖医学中心 210029
- Publication Type:Journal Article
- Keywords:
Oocyte;
Glucose metabolism;
Cumulus cells;
Nuclear maturation;
Cytoplasmic maturation
- From:
Chinese Journal of Reproduction and Contraception
2020;40(9):782-787
- CountryChina
- Language:Chinese
-
Abstract:
The energy consumed by oocyte maturation is partly derived from cumulus cells, but is mainly produced by oocyte mitochondria; the substrate for energy metabolism is glucose, followed by lipid and amino acids. Glucose can be metabolized by four pathways, namely glycolytic pathway, pentose phosphate pathway, hexosamine biosynthetic pathway and polyol pathway. The glycolytic pathway is one of the main metabolic pathways, but its efficiency is low when it is anaerobic or hypoxic. When it is aerobic, oocytes mainly metabolize glucose through the oxidative phosphorylation pathway of mitochondria.This paper reviews the role of glucose metabolism in oocyte maturation and the synchronization of oocyte nuclear and cytoplasmic maturation. It is expected to optimize the protocol of oocyte in vitro maturation by regulating glucose metabolism, which is beneficial to improve the quality and development potential of in vitromaturation oocyte.
