Immediate-type hypersensitivity induced by piperacillin sodium and tazobactam sodium
10.3760/cma.j.cn114015-20220411-00302
- VernacularTitle:哌拉西林钠他唑巴坦钠致速发型过敏反应
- Author:
Xiaoling HU
1
;
Yazhen NIU
1
;
Yadeng CUI
1
;
Shuai WANG
1
Author Information
1. 长治医学院附属和平医院药剂科，长治 046000
- Publication Type:Journal Article
- Keywords:
Allergic reaction;
Drug-related side effects and adverse;
Piperacillin
- From:
Adverse Drug Reactions Journal
2022;24(8):437-438
- CountryChina
- Language:Chinese
-
Abstract:
A 75-year-old male patient with pulmonary infection received an IV infusion of piperacillin sodium and tazobactam sodium 4.5 g twice daily. Fifteen minutes after the first medication, the patient developed patches on the skin of both upper limbs with pruritus, chest tightness and suffocation. Physical examination showed heart rate 110 beats/min, breathing rate 26 breaths/min, blood pressure 196/118 mmHg, and oxygen saturation 0.85. Immediate-type hypersensitivity related to piperacillin sodium and tazobactam sodium was considered. The drug was discontinued and symptomatic treatments including glucocorticoids and antiasthma were given. Two hours later, the skin itching was alleviated, the color of erythema became lighter, and the symptoms of chest tightness and suffocation were relieved. Physical examination showed that the heart rate was 100 beats/min, the blood pressure was 150/90 mmHg, and the blood oxygen saturation was 0.90.
