Metoclopramide hydrochloride injection-induced hypertensive crisis in a patient with pheochromocytoma
10.3760/cma.j.cn114015-20210909-00984
- VernacularTitle:盐酸甲氧氯普胺注射液致嗜铬细胞瘤患者高血压危象
- Author:
Xiaolin CHEN
1
;
Haixi LI
;
Jie YANG
;
Hai YANG
Author Information
1. 青岛市中心医院药学部，青岛 266042
- Publication Type:Journal Article
- Keywords:
Metoclopramide;
Pheochromocytoma;
Paraganglioma, extra-adrenal;
Medication errors;
Hypertensive crisis
- From:
Adverse Drug Reactions Journal
2022;24(7):371-373
- CountryChina
- Language:Chinese
-
Abstract:
A 64-year-old female patient with paraganglioma received intramuscular injection of metoclopramide hydrochloride injection 10 mg to prevent chemotherapy-induced vomiting. Five minutes later, he developed palpitation, sweating, headache, limb weakness, and other discomfort symptoms, and the blood pressure increased to 214/101 mmHg. Hypertensive crisis was diagnosed. Urapidil 25 mg was given intravenously, and the blood pressure in the patient was continuously monitored. About 12 hours later, the patient′s symptoms were improved and the blood pressure gradually returned to normal. It is suggested in the label that metoclopramide should not be used in patients with pheochromocytoma and paraganglioma. The patient suffered from hypertension crisis due to the use of the drug, and the hospital stay was prolonged, so it was grade F medication error.
