Analysis of the factors influencing clinical outcome in single frozen-thawed blastocyst transfer cycles
10.3760/cma.j.cn101441-20190628-00279
- VernacularTitle:冻融周期单囊胚移植临床结局的影响因素研究
- Author:
Yanan ZHANG
1
;
Juanke XIE
1
;
Yuanhui CHEN
1
;
Cuilian ZHANG
1
Author Information
1. 河南省人民医院，河南省生殖医院，河南省生殖医学工程国际联合实验室，郑州大学人民医院，河南大学人民医院 450000
- Publication Type:Journal Article
- Keywords:
Frozen-thawed embryo transfer;
Single blastocyst transfer;
Morphological scoring;
Clinical pregnancy rate;
Live birth rate
- From:
Chinese Journal of Reproduction and Contraception
2020;40(8):629-637
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the factors influencing clinical outcome in single frozen-thawed blastocyst transfer cycles.Methods:The clinical data of 1748 frozen-thawed single blastocyst transfer cycles were studied retrospectively in Reproductive Medical Center of Henan Provincial People’s Hospital from January 2011 to April 2018. The effects of the development speed of blastocysts, the different fertilization methods and morphological scoring of blastocyst on the pregnancy outcome were observed. Clinical pregnancy rate, biochemical pregnancy rate, early abortion rate and live birth rate were compared among different groups. Logistic regression analysis was performed to determine the correlation between these parameters and clinical pregnancy rate and live birth rate.Results:The biochemical pregnancy rate, the clinical pregnancy rate and the live birth rate of day 5 (D5) frozen-thawed single blastocyst transfer were significantly higher than those of day 6 (D6) ( P<0.05), while the ectopic pregnancy rate, the abortion rate and the early abortion rate had no significant difference ( P>0.05). Coincident results were obtained by comparing the clinical outcomes of D5/D6 blastocysts with the same score. The clinical outcome of the blastocyst of different fertilization methods had no significant differences ( P>0.05). According to the status of blastocoele expansion and hatching, blastocysts were divided into stages 3-6. Compared with the stage 3 and stage 6 groups, the stage 4 and stage 5 groups of D5 frozen-thawed single blastocyst transfer showed a higher biochemical pregnancy rate, clinical pregnancy rate, live birth rate and a lower early abortion rate, but there were no statistically significant differences ( P>0.05). In the stage 4 group of D5 frozen-thawed single blastocyst transfer cycles, there was a tendency of lower biochemical pregnancy rate, clinical pregnancy rate and live birth rate with lower inner cell mass （ICM） or trophectoderm （TE） score but without statistically significant differences ( P>0.05). It was found that the age of patients and the development speed of blastocysts were negatively related to the clinical pregnancy rate and pregnancy live birth rate, while the degree of blastocoele expansion and hatching was positively related to the clinical pregnancy rate, and ICM and TE score were negatively related to the live birth rate. Conclusion:The age of patients, the development speed of blastocysts and blastocyst quality could be the factors influencing clinical outcome in single frozen-thawed blastocyst transfer cycles.
