Ulcerative colitis associated with secukizumab injection
10.3760/cma.j.cn114015-20211210-01248
- VernacularTitle:司库奇尤单抗注射液相关溃疡性结肠炎
- Author:
Jie MA
1
;
Min LIU
;
Yidan CAO
;
Nan WANG
Author Information
1. 吉林大学第一医院临床药学部，长春 130021
- Publication Type:Journal Article
- Keywords:
Psoriasis;
Colitis, ulcerative;
Drug-related side effects and adverse reactions;
Secukinumab
- From:
Adverse Drug Reactions Journal
2022;24(7):380-382
- CountryChina
- Language:Chinese
-
Abstract:
A 37-year-old female patient with psoriasis received subcutaneous injection of secukinumab 300 mg once a week. Four weeks later, it was changed to subcutaneous injection of 300 mg once every 4 weeks. Seventy-five days later, the patient developed abdominal pain, diarrhea, and fever. The patient had no previous intestinal disease and family history of inflammatory bowel disease. Ulcerative colitis (initial, whole colon, and severe type) was diagnosed by enteroscopy, which was considered to be related to secukinumab. After 2 days of anti-inflammatory treatment with glucocorticoid, the patient′s body temperature returned to normal and the abdominal pain was alleviated; after 9 days, the patient only had a dull abdominal pain at night and no other discomfort occurred.
