Effect of glycolytic metabolic signal on differentiation of Th17 cells in rheumatoid arthritis
10.3969/j.issn.1000-484X.2025.09.010
- VernacularTitle:糖酵解代谢信号对类风湿关节炎中Th17细胞的影响
- Author:
Xue CHEN
1
;
Yu GE
1
;
Lingling ZHOU
1
Author Information
1. 南京中医药大学药学院,南京 210023
- Publication Type:Journal Article
- Keywords:
Glycolysis;
Glycolytic metabolic signaling;
Th17 cells;
Active ingredient of traditional Chinese medicine;
Rheu-matoid arthritis;
Autoimmune disease
- From:
Chinese Journal of Immunology
2025;41(9):2106-2116
- CountryChina
- Language:Chinese
-
Abstract:
Rheumatoid arthritis(RA)is a chronic autoimmune disease characterized by inflammation of synovial tissue.Ab-normal differentiation of Th17 cells may affect the progression of RA.Besides,the growth and function of Th17 cells depend on glycoly-sis.In this paper,the relationship between glycolysis-mediated differentiation of Th17 cells and the development of RA was discussed.Following that,the glycolytic metabolic signals were introduced in two aspects.These included Glut1,HK-Ⅱ,PFK-1,PFKFB3,PKM2,LDHA,and other glycolytic enzymes(proteins),as well as mTOR,HIF-1α,AMPK,NRs,and other glycolytic sensors.In addition,we displayed relevant research efforts on treating autoimmune disease,such as RA.These studies contribute to pertinent studies for the clinical treatment of RA by offering useful metabolic targets.Finally,the research progress on improving RA through the inhibition of glycolysis by active components of traditional Chinese medicine(TCM)was described,indicating the potential of TCM in targeting glycolytic metabolic signals for the treatment of autoimmune diseases.
