Multivariate analysis of the clinical outcome of 16 458 natural artificial insemination cycles with donor sperm

Qingjian ZHANG; Ge SONG; Xiaoying ZHONG; Ronghua JIANG; Xiaoling LIU; Weiwei ZHENG; Xiaoli ZHU; Minru LI; Zehu ZHAN; Xiaolin CAI; Qiao CHEN

Return

Multivariate analysis of the clinical outcome of 16 458 natural artificial insemination cycles with donor sperm

VernacularTitle:16 458个供精人工授精自然周期妊娠结局的多因素分析
Author: Qingjian ZHANG ¹ ; Ge SONG ¹ ; Xiaoying ZHONG ¹ ; Ronghua JIANG ¹ ; Xiaoling LIU ¹ ; Weiwei ZHENG ¹ ; Xiaoli ZHU ¹ ; Minru LI ¹ ; Zehu ZHAN ¹ ; Xiaolin CAI ¹ ; Qiao CHEN ¹
Author Information

1. 国家卫生健康委员会男性生殖与遗传重点实验室　广东省计划生育科学技术研究所生殖中心，广州　510600
Publication Type:Journal Article
Keywords: Artificial insemination with donor sperm; Pregnancy; Generalized estimating equation
From: Chinese Journal of Reproduction and Contraception 2020;40(8):620-628
CountryChina
Language:Chinese
Abstract: Objective:To analyze the effects of various factors on the clinical outcome of artificial insemination with donor sperm (AID) under natural cycles.Methods:A total of 16 458 natural cycles with donor sperm were analyzed from January 2011 to December 2018 in Reproductive Center of Guangdong Province Family Planning Science and Technology Research Institute. The relationship between the clinical outcome and the factors such as the women's character, donor sperm quality and cycle related factors with χ 2 and multiple factor generalized estimating equation. Results:Many factors such as women's age ≤ 30 years ( OR=1.865, P<0.001), the woman's age from 31 to 35 years ( OR=1.215, P<0.001), duration of infertility≤5 ( OR=1.139, P=0.007), day 3 luteining hormone (LH) level>8.10 IU/L ( OR=1.309, P=0.022), day 3 estrogen level≤77.10 pmol/L ( OR=1.301, P=0.012), day 3 estrogen level from 77.11 pmol/L to 293.60 pmol/L ( OR=1.099, P=0.044), one dominant follicle per cycle ( OR=1.473, P=0.038), cervical mucus score ≥10 ( OR=1.256, P=0.026), A type endometrium ( OR=1.114, P=0.005), urinary LH strong positive ( OR=1.171, P=0.002), sperm activity ratio more than 54% after thawing ( OR=1.142, P=0.002), progressively motile sperm number ≥ 35×10 6 after thawing ( OR=1.217, P=0.001) and double inseminations per cycle ( OR=1.376, P=0.001) significantly affected the pregnancy rates of AID women under natural cycles. Conclusion:Many factors such as the woman's age, duration of infertility, day 3 LH level, day 3 estrogen level, dominant follicle number per cycle, cervical mucus score, endometrial type, sperm activity ratio after thawing, progressively motile sperm number and insemination times per cycle can affect the women’s pregnancy rate under AID natural cycles.