Application of Jinfeng pill combined with long-acting gonadotropin-releasing hormone agonist for frozen-thawed embryo transfer
10.3760/cma.j.cn101441-20190611-00254
- VernacularTitle:金凤丸联合长效促性腺激素释放激素激动剂在冻融胚胎移植中的应用
- Author:
Dan ZHANG
1
;
Han ZHOU
;
Ying GUO
;
Xinxian ZHANG
;
Guimin HAO
;
Na CUI
;
Lei JIANG
;
Aimin YANG
;
Wei WANG
Author Information
1. 河北医科大学第二医院，石家庄 050000
- Publication Type:Journal Article
- Keywords:
Jinfeng pill;
Gonadotropin-releasing hormone agonist;
Frozen-thawed embryo transfer;
Artificial cycle
- From:
Chinese Journal of Reproduction and Contraception
2020;40(8):659-662
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the application value of Jinfeng pill combined with long-acting gonadotropin-releasing hormone agonist (GnRH-a) in frozen-thawed embryo transfer (FET).Methods:A retrospective analysis of 220 cases of FET in the Department of Reproductive Medicine, the Second Hospital of Hebei Medical University during January 1, 2017 and December 31, 2017 was performed. All cases were divided into Jinfeng pill combined with long-acting GnRH-a group (experimental group, n=102) and long-acting GnRH-a group (control group, n=118) according to whether the endometrium was prepared in combination with Jinfeng pill or not. The general data, embryo resuscitation rate, number of transplanted embryos, embryo implantation rate, clinical pregnancy rate, endometrial proliferation time, serum estradiol level on the day of endometrial transformation and endometrial thickness on the day of endometrial transformation were compared between the two groups. Results:Compared with control group, the experimental group had a shorter endometrial proliferation time [(14.03±3.39) d vs. (16.40±1.45) d, P<0.001], and the serum estradiol level was higher [(347.67±26.78) ng/L vs. (259.57±24.78) ng/L, P<0.001]. The endometrium on the endometrial transformation was thicker [(11.89±1.57) mm vs. (9.69±0.85) mm, P<0.001], the difference was statistically significant. The embryo implantation rate and the clinical pregnancy rate in experimental group were higher than those in control group (32.66% vs. 31.70%; 53.92% vs. 50.85%), but the difference was not statistically significant ( P>0.05). There were no significant differences in age, infertility duration, primary infertility ratio, anti-Müllerian hormone (AMH), antral follicle count (AFC), body mass index (BMI), number of thawing, embryo resuscitation rate, number of transplanted embryos, and multiple pregnancy rates between the two groups ( P>0.05). Conclusion:Jinfeng pill combined with long-effect GnRH-a can improve the pregnancy outcome of FET.
