Correlation between changes of peripheral blood immune cell level and severity of severe diseases in hand,foot and mouth disease investigated by a case-control study
10.3969/j.issn.1000-484X.2025.09.029
- VernacularTitle:手足口病患者外周血免疫细胞水平变化与重症程度关联的巢式病例对照研究
- Author:
Shan ZHENG
1
;
Huifen FENG
1
;
Jing XU
1
;
Shuang FENG
1
;
Jing YANG
1
Author Information
1. 郑州大学第五附属医院消化内科,郑州 450052
- Publication Type:Journal Article
- Keywords:
Hand,foot and mouth disease;
Immune cells;
Immune response
- From:
Chinese Journal of Immunology
2025;41(9):2232-2236
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the effect of peripheral blood immune cell level changes on the severity of hand,foot and mouth disease(HFMD).Methods:A total of 1 079 patients with mild and severe HFMD diagnosed and treated in The Fifth Affiliated Hospital of Zhengzhou University and Henan Children's Hospital from April 2015 to December 2018 were collected and divided into 5 subgroups according to the time from the onset of symptoms and signs to the first diagnosis.Trend of peripheral blood immune cells in each subgroup with the course of disease was plotted.Spearman coefficient and multiple Logistic regression analysis were used to screen risk factors of severe HFMD with the course of disease.Results:Univariate analysis indicated that levels of T cells,Ts and Th in severe group were lower than those in mild group,while levels of NK cells and B cells were higher than those in mild group(P<0.05).Correlation analysis showed a strong negative correlation between T cells and B cells(rs=-0.687)and NK cells(rs=-0.486).Logistic regression analysis showed that the reduction of immune cells(T cells,Ts,Th,LYM)in the course of disease from 1 to 5 days was statistically significant between mild and severe groups(P<0.05).Proportion of B cells was increased in mild and severe groups from 1～4 days(P<0.05),and NK cells was increased in mild and severe groups on day 2 of the course of disease(P<0.05).Proportion of severe patients living in rural areas with body temperature>39.0℃was significantly higher than that of mild patients(P<0.05).Conclusion:Disease progression of patients with severe HFMD is closely related to the disorder of immune cell regulatory function.Early monitoring of changes in peripheral blood lymphocyte subsets in HFMD patients can determine the progression of se-vere HFMD disease,and attention should be paid to changes in children living in rural areas with body temperature>39.0℃.
