Research progress of endoplasmic reticulum stress on diminished ovarian reserve
10.3760/cma.j.cn101441-20190601-00233
- VernacularTitle:卵巢储备功能减退的内质网应激机制及其研究进展
- Author:
Xiuru LIANG
1
;
Yan MENG
1
Author Information
1. 南京医科大学第一附属医院生殖医学中心 210029
- Publication Type:Journal Article
- Keywords:
Endoplasmic reticulum stress;
Diminished ovarian reserve;
Follicle atresia;
Steroid hormone;
Fibrosis
- From:
Chinese Journal of Reproduction and Contraception
2020;40(6):521-525
- CountryChina
- Language:Chinese
-
Abstract:
Diminished ovarian reserve (DOR) is characterized by reduced reproductive capacity and endocrine disorders, causing poor fertility outcomes. Endoplasmic reticulum (ER) is an important organelle responsible for several cellular functions, including synthesis and folding of proteins, lipid metabolism, steroid hormone synthesis and Ca 2+ storage. Various types of stress can disrupt ER homeostasis and induce ER stress, mainly unfolded protein response (UPR). At initial stage the UPR promotes cell survival, but along with excessive or prolonged stress it will lead to apoptosis. Recently more evidence demonstrates that ER stress is involved in the initiation of DOR and associated with follicle atresia, decreased hormone synthesis and ovarian fibrosis. This review will focus on the research progress of ER stress on DOR.
