Research progress of interleukin-27 in rheumatoid arthritis
10.3969/j.issn.1000-484X.2025.09.011
- VernacularTitle:白细胞介素-27在类风湿关节炎中的研究进展
- Author:
Le HAN
1
;
Xianzheng ZHANG
;
Lingling ZHANG
Author Information
1. 江阴市人民医院药学部,江阴 214400
- Publication Type:Journal Article
- Keywords:
Rheumatoid arthritis;
IL-27;
Inflammatory immune response;
Signal transduction
- From:
Chinese Journal of Immunology
2025;41(9):2117-2122
- CountryChina
- Language:Chinese
-
Abstract:
Rheumatoid arthritis(RA)is an autoimmune disease characterized by joint synovium inflammation and hyperpla-sia.IL-27 is a heterodimeric cytokine composed of p28 and EBI3.The binding of IL-27 to IL-27R leads to activation of JAK/STAT and p38/MAPK pathways,which plays anti-inflammatory and pro-inflammatory roles in the regulation of T/B cell differentiation and im-mune response,and participates in the occurrence and development of RA.In this paper,we have reviewed the structural characteris-tics,biological functions and research progress of IL-27,providing directions for exploring the pathogenesis and new therapeutic tar-gets of RA.
