Acute lung injury due to furazolidone
10.3760/cma.j.cn114015-20211011-01054
- VernacularTitle:呋喃唑酮致急性肺损伤
- Author:
Caiyan LIN
1
;
Danfang MA
;
Chongze CHEN
;
Feng WEI
Author Information
1. 福州市长乐区医院呼吸内科，福州 350200
- Publication Type:Journal Article
- Keywords:
Furazolidone;
Drug-related side effects and adverse reactions;
Acute lung injury
- From:
Adverse Drug Reactions Journal
2022;24(5):271-273
- CountryChina
- Language:Chinese
-
Abstract:
A 47-year-old female patient with Helicobacter pylori (HP) infection received anti-HP regimen, including pantoprazole enteric coated tablets 40 mg orally twice daily, amoxicillin capsules 1 g orally twice daily, and furazolidone tablets 0.1 g orally thrice daily. The patient had previously taken amoxicillin capsules and pantoprazole enteric coated tablets several times without adverse reactions. On the 12th day after receiving anti-HP treatment, the patient developed fever, shortness of breath, body temperature of 38.3 ℃, and conjunctival hemorrhage of the right eyeball. Laboratory tests showed that percentage of eosinophils was 0.08. Chest CT showed interstitial pulmonary edema in bilateral lungs and a small amount of effusion in the right pleural cavity. Acute lung injury associated with furazolidone was considered. Furazolidone was stopped. The patient received glucocorticoid and symptomatic treatments. Six days later, the patient′s symptoms such as fever and shortness of breath were relieved and the conjunctival hemorrhage in the right eye was absorbed; laboratory test showed that percentage of eosinophils was 0.008; the chest CT showed that the interstitial pulmonary edema in bilateral lungs was more absorbed than before and the pleural effusion on the right side was basically absorbed.
