Diagnostic value of epicardial adipose tissue thickness combined with serum ADAM10 and STIM1 for coronary heart disease
10.11958/20250781
- VernacularTitle:心外膜脂肪厚度联合血清ADAM10、STIM1对冠心病的诊断价值
- Author:
Peilu XU
1
;
Jianmin QIAO
;
Jing LI
;
Jianrong LIU
;
Shujun CHEN
;
Chunpeng JI
Author Information
1. 开滦总医院放射科(邮编 063000)
- Publication Type:Journal Article
- Keywords:
coronary disease;
epicardial adipose tissue thickness;
a disintegrin and metalloprotease 10;
stromal interaction molecule 1
- From:
Tianjin Medical Journal
2025;53(9):963-967
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the diagnostic value of epicardial adipose tissue(EAT)thickness combined with serum disintegrin metalloprotease 10(ADAM10)and stromal interaction molecule 1(STIM1)in coronary heart disease(CHD).Methods A total of 119 CHD patients were included as the study group,and 100 non-CHD patients in the same period were selected as the control group.The clinical data of the patients were collected.Serum ADAM10 and STIM1 levels were detected by enzyme-linked immunosorbent assay(ELISA).Color Doppler ultrasonography was applied to detect EAT thickness.Multivariate Logistic regression was used to analyze influencing factors of CHD occurrence.The diagnostic value of EAT thickness combined with serum ADAM10 and STIM1 levels in the diagnosis of CHD was analyzed by subject work characteristics(ROC)curves.Results The levels of triglycerides,low-density lipoprotein cholesterol(LDL-C),EAT thickness,serum ADAM10 and STIM1 were higher in the study group than those in the control group(P＜0.05).Logistic regression analysis showed that elevated EAT thickness,serum ADAM10,STIM1,triglyceride and LDL-C levels were independent risk factors for the occurrence of CHD(P＜0.05).ROC curve analysis showed that the area under the curve of EAT thickness combined with serum ADAM10 and STIM1 for the diagnosis of CHD[0.864(95%CI:0.811-0.907)]was higher than that of their respective individual diagnoses[0.801(95%CI:0.741-0.851),0.750(95%CI:0.687-0.806),respectively,0.799(95%CI:0.740-0.850)],and the sensitivity and specificity of the combined diagnosis were 82.35%and 83.00%,respectively.Conclusion EAT thickness,serum ADAM10 and STIM1 levels are obviously elevated in CHD patients,and the combination of the three tests has a high diagnostic value for CHD.
