Acute pancreatitis induced by tacrolimus in a patient after kidney transplantation
10.3760/cma.j.cn114015-20210510-00548
- VernacularTitle:他克莫司致肾移植术后患者急性胰腺炎
- Author:
Guangping LI
1
;
Jiangtao WU
;
Qi WANG
;
Bo CUI
;
Xu WANG
;
Lu LU
;
Tongwen OU
Author Information
1. 首都医科大学宣武医院泌尿外科，北京 100053
- Publication Type:Journal Article
- Keywords:
Immunosuppressive agents;
Kidney transplantation;
Pancreatitis;
Tacrolimus
- From:
Adverse Drug Reactions Journal
2022;24(4):213-215
- CountryChina
- Language:Chinese
-
Abstract:
A 38-year-old female patient with uraemia received tacrolimus 1 mg orally twice daily after kidney transplantation. The serum trough concentration of tacrolimus was 9.8 μg/L on the 15th day. On the 17th day, the patient developed abdominal pain, nausea, and vomiting. The abdominal CT showed that the volume of pancreas increased, the edge was irregular, and obvious exudation appeared around the pancreas and in the abdominal cavity. Laboratory tests showed blood amylase 430 U/L and lipase 231 U/L.The acute pancreatitis related to tacrolimus was considered. Tacrolimus was stopped and replaced by cyclosporine A 100 mg orally twice daily. Meanwhile, symptomatic and supportive treatments such as fasting, gastrointestinal decompression, lipid-lowering, acid inhibition, anti-infection, and parenteral nutrition were given. Three days later, the above symptoms were relieved. Nineteen days later, laboratory tests showed blood amylase 173 U/L and lipase 51 U/L; abdominal CT showed that the outline of the pancreas was clearer than before, and the exudation around was significantly reduced.
