Analysis and prediction of the correlations between morphological and dosimetric parameters in different locations of esophageal cancer based on multi-to-multi double screening stepwise regression method
10.3969/j.issn.1005-202X.2024.12.005
- VernacularTitle:基于多对多双重筛选逐步回归法进行不同位置食管癌形态学和剂量学的相关性分析及预测
- Author:
Wenjuan ZHAO
1
;
Bichun XU
;
Di CHEN
;
Fubin ZENG
;
Jie HE
;
Linzhen LAN
;
Yusha ZENG
;
Huojun ZHANG
Author Information
1. 上海理工大学健康科学与工程学院,上海 200093;海军军医大学附属上海长海医院放疗科,上海 200433
- Publication Type:Journal Article
- Keywords:
esophageal cancer;
intensity-modulated radiotherapy;
multi-to-multi double screening stepwise regression method
- From:
Chinese Journal of Medical Physics
2024;41(12):1486-1493
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the correlation between morphological and dosimetric parameters in patients with esophageal cancer at different locations using multi-to-multi double screening stepwise regression method,and to make simple predictions.Methods A retrospective analysis was conducted on 105 patients with advanced esophageal cancer who underwent radiotherapy at the First Affiliated Hospital of Fujian Medical University from 2019 to 2021.Morphological parameters of organs-at-risk were collected from CT images,and intensity-modulated radiotherapy plans were developed using Raystation4.7.The prescription doses for PTV-G and PTV-C were 60 Gy/30 F and 54 Gy/30 F,respectively.Multi-to-multi double screening stepwise regression method was employed to analyze the correlation between morphological and dosimetric parameters in esophageal cancer patients,and some preliminary predictions were provided.Results The dosimetric volume parameters of the lungs and heart were correlated with PTV-G volume,PTV-G length,PTV-G cross-sectional area,left and right lung volumes,lung length and total lung volume(P<0.05).For upper thoracic esophageal cancer,dosimetric volume parameters of the lungs and heart were correlated with PTV-G volume,PTV-G length,and right lung volume(P<0.05).For middle thoracic esophageal cancer,dosimetric volume parameters of the lungs,heart,and spinal cord were correlated with PTV-G volume,PTV-G length,PTV-G cross-sectional area,left and right lung volumes,and lung length(P<0.05).For lower thoracic esophageal cancer,dosimetric volume parameters of the lungs,heart,and spinal cord were correlated with PTV-G volume,PTV-G length,right lung volume,and lung length(P<0.05).Conclusion For patients with tumors at different locations,both overall and segmental analyses should be considered to balance therapeutic effect and side effects of radiotherapy,thereby maximizing the benefits for tumor patients.
