Efficacy and safety of preoperative short-course radiotherapy combined with neoadjuvant chemotherapy in the treatment of locally advanced mid-low rectal cancer
10.3969/j.issn.1005-202X.2024.12.004
- VernacularTitle:术前短程放疗联合新辅助化疗治疗中低位局部进展期直肠癌效果及安全性分析
- Author:
Xufei GUO
1
Author Information
1. 柳州市人民医院肿瘤科,广西 柳州 545000
- Publication Type:Journal Article
- Keywords:
short-course radiotherapy;
neoadjuvant chemotherapy;
locally advanced mid-low advanced rectal cancer
- From:
Chinese Journal of Medical Physics
2024;41(12):1481-1485
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the clinical efficacy of preoperative short-course radiotherapy combined with neoadjuvant chemotherapy in locally advanced mid-low rectal cancer.Methods Eighty patients with locally advanced mid-low advanced rectal cancer were enrolled and assigned to single group(preoperative neoadjuvant chemotherapy,n=32)and combination group(preoperative short-course radiotherapy+neoadjuvant chemotherapy,n=48)according to different treatment methods.All of them underwent total mesorectal resection after chemoradiotherapy.The two groups were compared for clinical curative effect,serum tumor markers[carcinoembryonic antigen(CEA),carbohydrate antigen 125(CA125),CA199]and immune function(CD3+,CD4+,CD8+)before and after chemoradiotherapy;and the incidence of adverse reactions during chemoradiotherapy was recorded.Results The overall remission rate was higher in combination group than in single group(37.50%vs 15.63%,P<0.05).After chemoradiotherapy,the levels of serum CEA,CA125 and CA199 in both groups were decreased,and they were lower in combination group than in single group(P<0.05).After chemoradiotherapy,the levels of CD3+and CD4+in single group and combination group increased,and the level of CD8+decreased(P<0.05),but there was no statistically significant differences in the above indicators between two groups(P>0.05).Additionally,the difference in adverse reactions between two group was trivial(P>0.05),and no grade-IV adverse reactions occurred in either group.Conclusion The combination of preoperative short-course radiotherapy and neoadjuvant chemotherapy is effective for locally advanced mid-low advanced rectal cancer,and beneficial for increasing overall remission rate and lowering the levels of serum tumor markers,with high safety.
