Physical activity, long-term fine particulate matter exposure and type 2 diabetes incidence: A prospective cohort study
- VernacularTitle:Physical activity, long-term fine particulate matter exposure and type 2 diabetes incidence: A prospective cohort study
- Author:
Qian LI
1
;
Fangchao LIU
;
Keyong HUANG
;
Fengchao LIANG
;
Chong SHEN
;
Jian LIAO
;
Jianxin LI
;
Chenxi YUAN
;
Xueli YANG
;
Jie CAO
;
Shufeng CHEN
;
Dongsheng HU
;
Jianfeng HUANG
;
Yang LIU
;
Xiangfeng LU
;
Dongfeng GU
Author Information
- Publication Type:Journal Article
- Keywords: fine particulate matter; physical activity; type 2 diabetes
- From: Chronic Diseases and Translational Medicine 2024;10(3):205-215
- CountryChina
- Language:English
- Abstract: Background::Despite the adverse effects of ambient fine particulate matter (PM 2.5) on type 2 diabetes and the beneficial role of physical activity (PA), the influence of PM 2.5 on the relationship between PA and type 2 diabetes remains unclear. Methods::In this prospective study with 71,689 participants, PA was assessed by a questionnaire and was categorized into quartiles for volume and three groups for intensity. Long-term PM 2.5 exposure was calculated using 1-km resolution satellite-based PM 2.5 estimates. PM 2.5 exposure and PA's effect on type 2 diabetes were assessed by cohort-stratified Cox proportional hazards models, individually and in combination. Results::In 488,166 person-years of follow-up, 5487 incident type 2 diabetes cases were observed. The association between PA and type 2 diabetes was modified by PM 2.5. Compared with the lowest quartile of PA volume, the highest quartile was associated with reduced type 2 diabetes risk in low PM 2.5 stratification (≤65.02 μg/m 3) other than in high PM 2.5 stratification (>65.02 μg/m 3), with the hazard ratio (HR) of 0.75 (95% confidence interval [CI]: 0.66-0.85) and 1.10 (95% CI: 0.99-1.22), respectively. Similar results were observed for PA intensity. High PM 2.5 exposure combined with the highest PA levels increased the risk of type 2 diabetes the most (HR= 1.79, 95% CI: 1.59-2.01 for PA volume; HR = 1.82, 95% CI: 1.64-2.02 for PA intensity). Conclusion::PA could reduce type 2 diabetes risk in low-pollution areas, but high PM 2.5 exposure may weaken or even reverse the protective effects of PA. Safety and health benefits of PA should be thoroughly assessed for long-term polluted residents.
