The lack of association between different LDL-C levels and oxidized LDL in patients with type 2 diabetes

Soghra RABIZADEH; Seyedi Seyed ARSALAN; Nabipoorashrafi Seyed ALI; Siahkalmahalleh Maryamossadat OMIDVAR; Amirhossein YADEGAR; Fatemeh MOHAMMADI; Armin RAJAB; Alireza ESTEGHAMATI; Manouchehr NAKHJAVANI

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The lack of association between different LDL-C levels and oxidized LDL in patients with type 2 diabetes

VernacularTitle:The lack of association between different LDL-C levels and oxidized LDL in patients with type 2 diabetes
Author: Soghra RABIZADEH ¹ ; Seyedi Seyed ARSALAN ¹ ; Nabipoorashrafi Seyed ALI ¹ ; Siahkalmahalleh Maryamossadat OMIDVAR ¹ ; Amirhossein YADEGAR ¹ ; Fatemeh MOHAMMADI ¹ ; Armin RAJAB ¹ ; Alireza ESTEGHAMATI ¹ ; Manouchehr NAKHJAVANI ¹
Author Information

1. Endocrinology and Metabolism Research Center (EMRC), Vali-Asr Hospital, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
Publication Type:Journal Article
Keywords: atherosclerosis; diabetes mellitus; lipids; lipoproteins; low-density lipoprotein; oxidized LDL
From: Chronic Diseases and Translational Medicine 2023;09(4):329-335
CountryChina
Language:English
Abstract: Background::High concentrations of low-density lipoprotein cholesterol (LDL-C) have been a known risk factor for cardiovascular diseases. Also, the role of oxidized LDL (ox-LDL) in forming atherosclerosis plaque has been proven. However, it has not yet been proven that atherogenic LDL-C by-products like ox-LDL will decrease by keeping the LDL levels at the desired level. This study aimed to examine the relationship between LDL-C and ox-LDL in different LDL-C values in patients with type 2 diabetes (T2D).Methods::In this cross-sectional study, 347 patients with T2D who received statins were enrolled. LDL-C values were defined into four groups as LDL-C < 55 mg/dL, 55 mg/dL ≤ to <70 mg/dL, 70 mg/dL ≤ to <100 mg/dL and LDL-C ≥ 100 mg/dL. Total cholesterol, triglyceride (TG), high-density lipoprotein cholesterol (HDL-C), and ox-LDL were studied in the four defined groups.Results::Ox-LDL levels were not different among the four groups ( p = 0.30). In addition, LDL-C and ox-LDL levels had no significant correlation (r = 0.480, p = 0.376). Additionally, based on this study analysis, ox-LDL levels were significantly correlated with TG levels ( r = 0.119, p < 0.05) and TG/HDL ratio ( r = 0.390, p < 0.01). Conclusions::It is concluded that ox-LDL levels were not associated with different LDL-C level categories from <55 mg/dL to >100 mg/dL in patients with T2D. However, the revealed association of ox-LDL with TG level and TG/HDL ratio may be considered in the clinic.