Rapid detection of illicit drugs in blood based on surface-enhanced Raman spectroscopy
10.13618/j.issn.1001-5728.2024.06.013
- VernacularTitle:基于表面增强拉曼光谱技术的血液中苯二氮卓类药物快速检测方法
- Author:
Liang SHEN
1
;
Renxiang ZHU
;
Fang CHEN
;
Biyun SHI
;
Wukui ZHONG
;
Junjun GUO
Author Information
1. 绍兴市公安局柯桥区分局,浙江 绍兴 312030
- Publication Type:Journal Article
- Keywords:
SERS;
Alprazolam;
Nitrovalam;
Temazepam;
Diazepam;
Chlorazepine;
Quick detection
- From:
Chinese Journal of Forensic Medicine
2024;39(6):706-709,716
- CountryChina
- Language:Chinese
-
Abstract:
Objective To establish a rapid surface-enhanced Raman spectroscopy(SERS)method for detection of five banned benzodiazepines in blood,including alprazolam,nitrovalam,Temazepam,diazepam and cloazepine.Methods Ethanol was used as extraction agent to extract nitrodiazepam,nitrazepam,diazepam and clonazepam from blood,a mixture of PSA and C18 was added for optimization,and SERS technology was used for detection.Results Experiments showed that nitalprazolam,nitrodiazepam,Temazepam,diazepam and chlorazepine all had corresponding Raman characteristic signal peaks,which could be used as the basis for qualitative discrimination.The detection limits of these benzodiazepines in blood were between 0.5 and 1 μg/mL.Conclusion This method is simple to operate and has a fast analysis speed.It is suitable for the rapid detection of drugs in blood samples.
