Prognostic role of C-reactive protein to albumin ratio in lung cancer: An updated systematic review and meta-analysis
- VernacularTitle:Prognostic role of C-reactive protein to albumin ratio in lung cancer: An updated systematic review and meta-analysis
- Author:
Zhendong LU
1
;
Siyun FU
;
Wei LI
;
Xiang GAO
;
Jinghui WANG
Author Information
- Publication Type:Journal Article
- Keywords: C-reactive protein to albumin ratio; inflammation: biomarker; lung cancer; prognosis
- From: Chronic Diseases and Translational Medicine 2024;10(1):31-39
- CountryChina
- Language:English
- Abstract: Background::C-reactive protein to albumin ratio (CRP/Alb ratio, CAR) has been suggested as a potential prognostic biomarker in lung cancer. This updated systematic review and meta-analysis aimed to assess the association between CAR and lung cancer prognosis in current literature.Methods::A systematic search of databases was conducted to identify relevant studies published up to April 2023. Pooled hazard ratios (HRs) and 95% confidence intervals (CIs) were calculated to assess the association between CAR and overall survival (OS) and progression-free survival (PFS) and recurrence-free survival (RF) in lung cancer patients.Results::This meta-analysis includes 16 studies with a total of 5337 patients, indicating a significant association between higher CAR and poorer OS, PFS, and RFS in lung cancer patients, with a pooled HR of 1.78 (95% CI = 1.60–1.99), 1.57 (95% CI = 1.36–1.80), and 1.97 (95% CI = 1.40–2.77), respectively.Conclusions::This updated meta-analysis provides evidence for the potential prognostic role of CAR in lung cancer, suggesting its utility as an effective and noninvasive biomarker for identifying high-risk patients and informing treatment decisions in a cost-effective manner. However, further large-scale studies will be necessary to establish the optimal cut-off value for CAR in lung cancer and confirm the present findings.
