Dynamic functional connectivity analysis of insomnia patients based on triple brain network model
10.3969/j.issn.1005-202X.2025.08.004
- VernacularTitle:基于三重脑网络模型的失眠患者动态功能连接分析
- Author:
Wuyuan XIN
1
;
Juan WANG
;
Yongxin CHENG
;
Daining SONG
;
Junxuan WANG
;
Yuxin MA
;
Ting XUE
;
Jingjing DING
;
Dahua YU
;
Kai YUAN
Author Information
1. 内蒙古科技大学数智产业学院,内蒙古 包头 014010
- Publication Type:Journal Article
- Keywords:
insomnia;
functional magnetic resonance imaging;
dynamic functional network connectivity;
brain network
- From:
Chinese Journal of Medical Physics
2025;42(8):1004-1010
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the dynamic functional connectivity differences between insomnia patients and healthy controls in triple brain networks[the significant network(SN),the default mode network(DMN),and the executive control network(ECN)]using functional magnetic resonance imaging,and uncover their associations with cognitive ability.Methods Dynamic functional connectivity analysis was performed on functional magnetic resonance imaging data from 40 insomnia patients and 40 healthy controls.The changes in dynamic functional connectivity values were studied for SN,DMN,ECN[including the left executive control network(LECN)and the right executive control network(RECN)];the similarities and differences in time characteristic indicators such as time score,average dwell time,and conversion rate were explored;and their associations with clinical information were analyzed.Results The SN-LECN and DMN-RECN dynamic functional connectivity was significantly higher in insomnia patients than in healthy controls(P=0.013,0.047),while the RECN-LECN and RECN internal functional connectivity strength was lower in insomnia patients than in healthy controls(P<0.001).Additionally,the fractional time in state 2 in insomnia group was significantly higher than that in healthy controls(P<0.001),and it was positively correlated with the Pittsburgh sleep quality index(r=0.524,P=0.001).Conclusion Insomnia patients exhibit significant abnormalities in triple brain network dynamic functional connectivity,which may be related to abnormalities in cognitive control and sensory processing in insomnia patients.These findings provide a new perspective for further research on the neural mechanisms and potential intervention strategies for insomnia.
