Research Progress of Cellular Mechanosensors Mediating Cancer Pain
10.16156/j.1004-7220.2025.04.033
- VernacularTitle:细胞力学传感器介导癌痛的研究进展
- Author:
Chang LIU
1
;
Haiyan LI
;
Lihua HANG
Author Information
1. 南京医科大学姑苏学院;昆山市第一人民医院麻醉科,江苏苏州 215300;昆山市癌痛防治重点实验室,江苏苏州 215300
- Publication Type:Journal Article
- Keywords:
PIEZO;
TRPV4;
integrin;
cancer pain;
cellular mechanosensor;
mechanical transduction
- From:
Journal of Medical Biomechanics
2025;40(4):1040-1049
- CountryChina
- Language:Chinese
-
Abstract:
Cellular mechanical transduction is the process by which cells perceive mechanical signals and transform them into chemical ones.Crucial cellular mechanosensors include PIEZO,TRPV4,and integrins.These sensors can modulate specific pathophysiological processes,such as fibrosis,tumor development,as well as cell proliferation,differentiation,and movement.Recent researches indicate that PIEZO,TRPV4,and integrins play an important role in various types of cancer pain,such as bone cancer pain,by detecting mechanical stimuli,which subsequently activate internal signaling pathways.This review summarizes advancements of PIEZO,TRPV4,and interegrins in cancer pain researches,aiming to lay a foundation for developing new therapeutic drugs that target cellular mechanical transduction for treating cancer pain.
