Diagnostic value of MRI plain scan combined with contrast-enhanced scan in cervical cancer staging
10.3969/j.issn.1005-202X.2025.08.011
- VernacularTitle:MRI平扫及增强扫描对宫颈癌分期的诊断价值
- Author:
Daoming LI
1
;
Ling YANG
Author Information
1. 绵阳四〇四医院(绵阳市第一人民医院)放射科,四川 绵阳 621000
- Publication Type:Journal Article
- Keywords:
cervical cancer;
tumor staging;
magnetic resonance imaging;
plain scan;
contrast-enhanced scan
- From:
Chinese Journal of Medical Physics
2025;42(8):1052-1056
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the value of magnetic resonance imaging(MRI)plain scan and contrast-enhanced scan in the staging of cervical cancer.Methods A cohort of 82 cervical cancer patients were enrolled and stratified into 3 pathological stages(Ⅰ,Ⅱ,and Ⅲ-Ⅳ).Concurrently,30 healthy volunteers served as controls.All participants underwent MRI plain scan and dynamic contrast-enhanced MRI(DCE-MRI).Through the comparative analysis of DCE-MRI parameters between healthy controls and cervical cancer patients,and stratified evaluation across stages Ⅰ,Ⅱ,and Ⅲ-,the relationships of DCE-MRI parameters with tumor type,differentiation grade,and lymph node metastasis in cervical cancer patients were explored,and the diagnostic performances of MRI plain scan and DCE-MRI in cervical cancer staging were compared.Results The volume transfer constant(Ktrans),rate constant(Kep),and extracellular extravascular volume fraction(Ve)demonstrated significant elevations in cervical cancer patients compared to healthy controls(P<0.05).Stage Ⅲ-patients exhibited the highest Ktrans,Kep,and Ve,followed by stage Ⅱ patients and stage Ⅰ patients.All inter-stage comparisons reached statistical significance(P<0.05).The Ktrans and Ve in patients with adenocarcinoma were higher than those in patients with squamous cell carcinoma;the poorly differentiated exhibited the highest Ktrans,Kep,and Ve,followed by the moderately differentiated and the high differentiated;and those with lymph node metastasis demonstrated significantly elevated Ktrans and Kep than those without lymph node metastasis(P<0.05).The areas under the curve(AUC)of MRI plain scan,Ktrans,Kep,and Ve for diagnosing stage Ⅲ-cervical cancer were 0.678,0.775,0.731,and 0.695,respectively.The MRI plain scan combined with DCE-MRI demonstrated superior diagnostic performance(AUC=0.859)over individual parameters,with a sensitivity of 90.91％and a specificity of 67.61％.Conclusion The combination of MRI plain scan and DCE-MRI is of high value in cervical cancer staging.
