Influences of Oxygen Supply Flow Rate in High-Flow Nasal Cannula Oxygen Therapy on Pressure Distributions in the Upper Airway:A Numerical and Physical Simulation Research
10.16156/j.1004-7220.2025.04.031
- VernacularTitle:经鼻高流量氧疗供氧流量对上呼吸道中气压分布影响的数值与实体仿真研究
- Author:
Shuo JIA
1
;
Yawei WANG
;
Chunjing TAO
;
Jianjun LIU
;
Jialong LIU
;
Yubo FAN
Author Information
1. 北京航空航天大学北航-谊安联合实验室,北京 100083;北京谊安医疗系统股份有限公司,北京 100070
- Publication Type:Journal Article
- Keywords:
high-flow nasal cannula(HFNC);
oxygen therapy;
positive end expiratory pressure(PEEP);
computational fluid dynamics;
numerical simulation;
physical simulation
- From:
Journal of Medical Biomechanics
2025;40(4):1027-1033
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the influence of oxygen supply flow rate in high-flow nasal cannula(HFNC)oxygen therapy on pressure distributions in the upper airway.Methods A three-dimensional(3D)model of the upper airway was reconstructed using CT images from an adult male,and then coupled with a high-flow nasal cannula model to establish a coupled model of the nasal cannula and the upper airway.Subsequently,a physical model of this upper airway,which was combined with a head model,artificial lungs,and a monitoring system was created by 3D printing technology to form a physical simulation platform in vitro.Computational and physical simulations were carried out respectively to determine the air pressure at typical locations in the upper airway under different oxygen supply flow rates.Results Pressures at typical upper airway locations obtained by computational and physical simulations turned out to be in good agreement;both peak inspirational pressure(PIP)and positive end-expiratory pressure(PEEP)increased quadratically with the increase of oxygen supply flow rate;and the air pressure distribution was more uniform in the laryngeal cross-section as compared to the nasal part of the upper airway.Conclusions This study may provide a theoretical support for optimization of the setting of oxygen suppy flow rate and the selection of PEEP effect assessment position in the clinical application of HFNC oxygen therapy.
