Value of apparent diffusion coefficient in predicting efficacy of neoadjuvant concurrent chemoradiotherapy for rectal cancer
10.19745/j.1003-8868.2024237
- VernacularTitle:表观弥散系数在直肠癌新辅助同步放化疗疗效预测中的价值
- Author:
Yi-peng SU
1
;
Yi-ting CHEN
;
Ze-bang GUO
;
Shi-ying ZHENG
;
Guo-wang QIN
;
Yun-yun ZHU
;
Zhi-chao FU
Author Information
1. 福建医科大学基础医学院,福州 350100
- Publication Type:Journal Article
- Keywords:
apparent diffusion coefficient;
rectal cancer;
neoadjuvant concurrent chemoradiotherapy;
efficacy prediction;
diffusion weighted imaging
- From:
Chinese Medical Equipment Journal
2024;45(12):61-66
- CountryChina
- Language:Chinese
-
Abstract:
Objective To discuss the value of the apparent diffusion coefficient(ADC)in the prediction of therapeutic effect of neoadjuvant concurrent chemoradiotherapy(nCRT)in rectal cancer.Methods The clinical data of 52 patients with pathologi-cally diagnosed rectal cancer who underwent neoadjuvant chemoradiotherapy(nCRT)and received pelvic MR1 examinations before and 8 weeks after nCRT at the 900th Hospital of Joint Logistics Support Force from January 2019 to February 2023 were analyzed retrospectively.The ADC values before and after nCRT were obtained,and ΔADC and ΔADC％were calculated.The 52 patients were divided into a sensitive group(n=40)and a non-sensitive group(n=12)based on the tumor regression grade(TRG).The ADC values before nCRT,ΔADC and ΔADC％of the above two groups were compared by Mann-Whitney U test.The ADC values after nCRT of the two groups were compared by independent samples t-test.Spearman's rank correlation coefficient was used to evaluate the correlation of ΔADC and ΔADC％with TRG.The baseline data of the two groups were compared by independent samples t-test,Mann-Whitney U test and chi-square test.Binary Logistic regression was used to analyze the factors predicting efficacy.ROC was drawn to assess the ability of ΔADC in predicting nCRT efficacy,and determine optimal cut-off value.Results There was no statistical difference between the sensitive group and the non-sensitive group with regard to ADCs before and after nCRT(P＞0.05).There were statistical differences between the above two groups with regard to ΔADC and ΔADC％(P＜0.05).ΔADC and ΔADC％showed negative correlation with TRG(r=-0.378,-0.368,P＜0.05).Univariate analysis showed that there were statistically significant differences in tumor diameter between the two groups(P＜0.05).Multivariate analysis showed that ΔADC was an independent predictor of the efficacy.ROC curve analysis showed the optimal cut-off value of ΔADC was 236.600×10-6 mm2/s.Conclusion The ADC values before and after nCRT have limited predictive significance for assessing the efficacy of nCRT,whereas ΔADC can predict nCRT efficacy effectively and provide references for subsequent clinical treatment.[Chinese Medical Equipment Journal,2024,45(12):61-66]
