Clinical efficacy of trimetazidine combined with Wenxin granule in patients with heart failure and its influence on serum inflammatory markers
10.3969/j.issn.1008-0074.2024.06.23
- VernacularTitle:曲美他嗪联合稳心颗粒治疗心力衰竭患者的临床疗效及对血清炎症指标的影响
- Author:
Jing-hua MAO
1
;
Rong-ga ZHANG
1
;
Yuan LI
1
Author Information
1. 马鞍山十七冶医院药剂科,安徽马鞍山 243000
- Publication Type:Journal Article
- Keywords:
Heart failure;
Trimetazidine;
Wenxin granule
- From:
Chinese Journal of cardiovascular Rehabilitation Medicine
2024;33(6):762-766
- CountryChina
- Language:Chinese
-
Abstract:
Objective:This study aims to investigate the clinical efficacy of trimetazidine combined with Wenxin granule in patients with heart failure(HF)and its influence on serum inflammatory markers.Methods:This randomized controlled study enrolled 120 HF patients admitted in Maanshan Shiqiye Hospital between January 2018 and June 2019.The patients were divided into control group(n=60,trimetazidine therapy)and combined treatment group(n=60,trimetazidine com-bined Wenxin granule treatment).One month was regard as a course.After 3 continuous courses,clinical therapeutic effect,inflammatory factors,cardiac function and incidence of adverse reactions were compared between two groups.Re-sults:Total effective rate of combined treatment group was significantly higher than that of control group(96.7％vs.71.7％,P＜0.001).Compared with participants in control group after treatment,those in combined treatment group had significant lower interleukin(IL)-6[(53.63±6.34)ng/L vs.(45.23±6.12)ng/L],IL-17[(9.68±3.37)ng/L vs.(7.55±2.69)ng/L],tumor necrosis factor(TNF-α)[(13.81±2.13)ng/L vs.(10.29±1.04)ng/L],brain natriuretic peptide(BNP)[(98.65±10.23)ng/L vs.(51.28±8.16)ng/L],left ventricular end-diastolic diameter(LVEDd)[(50.71±6.78)mm vs.(42.32±6.39)mm]and left ventricular end-systolic diameter(LVESd)[(42.43±3.56)mm vs.(33.91±3.25)mm],and significant higher left ventricular ejection fraction(LVEF)[(44.92±4.36)％vs.(54.23±4.27)％](P＜0.001 all).We detected significant lower incidence of adverse reactions(8.3％vs.23.3％,P=0.024)in combined treatment group compared to control group.Conclusion:Trimetazidine combined with Wenxin granule is effec-tive in patients with heart failure,which could significantly reduce serum inflammatory factors,improve cardiac function and reduce incidence of adverse reactions.
