Influence of Xinmailong injection on cardiac function and serum inflammatory indexes in patients with coronary heart disease and heart failure
10.3969/j.issn.1008-0074.2024.06.22
- VernacularTitle:心脉隆注射液对冠心病心力衰竭患者心功能及血清炎症指标的影响
- Author:
Jia-jia TANG
1
;
Jing-jing CHEN
;
Yu-meng XU
;
Xiong MIAO
Author Information
1. 海安市人民医院药剂科,江苏南通 226600
- Publication Type:Journal Article
- Keywords:
Coronary disease;
Heart failure;
Xinmailong injection;
Inflammation
- From:
Chinese Journal of cardiovascular Rehabilitation Medicine
2024;33(6):757-761
- CountryChina
- Language:Chinese
-
Abstract:
Objective:This study aims to investigate the influence of Xinmailong injection on cardiac function and ser-um inflammatory indexes in patients with coronary heart disease(CHD)and heart failure(HF).Methods:This ran-domized controlled study enrolled 150 CHD+HF patients admitted in Hai'an People's Hospital between August 2019 and July 2020.They were divided into control group(n=75,routine anti-HF therapy)and combined treatment group(n=75,Xinmailong injection treatment based on control group).After 7d treatment,clinical therapeutic effect,symptom improvement time,cardiac function,serum inflammatory indexes and incidence of adverse reac-tions were compared between two groups.Results:The total effective rate in combined treatment group was signifi-cantly higher than that of control group(93.33％vs.80.00％,P=0.016).Compared with patients in control group after treatment,those in combined treatment group had significant shorter improvement time of pulmonary rales,systemic edema and dyspnea,significant higher cardiac output(CO),left ventricular ejection fraction(LVEF),6min walking distance(6MWD)and vascular endothelial growth factor(VEGF)level,and significant lower left ventricular end-diastolic diameter(LVEDd),levels of N terminal pro brain natriuretic peptide(NT-proBNP)and high sensitive C reactive protein(hsCRP)(P＜0.001 all).We detected no obvious adverse reactions in two groups during treatment.Conclusion:Routine anti-HF treatment combined with Xinmailong injection could not only effectively improve cardiac function,but also relieve inflammation in patients with coronary heart disease and heart failure,and its clinical efficacy and safety are both good.
